WASHINGTON – The U.S. Drug Enforcement Administration today announced the results of an
enforcement operation that spanned from May to September and resulted in significant fentanyl
seizures across the United States.
As part of the One Pill Can Kill initiative, the DEA and its law enforcement partners seized more than
10.2 million fentanyl pills and approximately 980 pounds of fentanyl powder during the period of May
23 through Sept. 8, 2022. The amount of fentanyl taken off the streets during this surge is equivalent to
more than 36 million lethal doses removed from the illegal drug supply. Additionally, 338 weapons
were seized, including rifles, shotguns, pistols, and hand grenades.
Of the 390 cases investigated during this period, 51 cases are linked to overdose poisonings and 35
cases link directly to one or both of the primary Mexican cartels responsible for the majority of
fentanyl in the United States – the Sinaloa Cartel and the Jalisco New Generation Cartel (CJNG). In
addition, 129 investigations are linked to social media platforms, including Snapchat, Facebook
Messenger, Instagram, and TikTok. These results build upon the One Pill Can Kill Phase II results
announced by DEA Administrator Anne Milgram in December 2021.
“Across the country, fentanyl is devastating families and communities, and we know that violent,
criminal drug cartels bear responsibility for this crisis,” said Attorney General Merrick B. Garland.
“The Justice Department, including the extraordinary professionals of the DEA, is working to disrupt
and dismantle the operations of these cartels, remove deadly fentanyl from our communities, and save
“For the past year, confronting the fentanyl crisis has been the top priority for DEA. The most urgent
threat to our communities, our kids, and our families are the Sinaloa Cartel and CJNG who are mass
producing and supplying the fentanyl that is poisoning and killing Americans,” said DEA
Administrator Anne Milgram. “The Sinaloa Cartel and CJNG are ruthless, criminal organizations that
use deception and treachery to drive addiction with complete disregard for human life. To save
American lives, the DEA is relentlessly focused on defeating the Sinaloa Cartel and CJNG by
degrading their operations to make it impossible for them to do business.”
Fentanyl remains the deadliest drug threat facing this nation. In 2021, a record number of Americans –
107,622 – died from a drug poisoning or overdose. Sixty-six percent of those deaths can be attributed
to synthetic opioids such as fentanyl.
Drug traffickers have expanded their inventory to sell fentanyl in a variety of bright colors, shapes, and
sizes. Rainbow fentanyl was first reported to DEA in February 2022, and it has now been seized in 21
Fentanyl is a synthetic opioid that is 50 times more potent than heroin. Just two milligrams of fentanyl,
or the amount that could fit on the tip of a pencil, is considered a potentially lethal dose.
As part of DEA’s ongoing efforts to educate the public and encourage parents and caregivers to talk to
teens and young adults about the dangers of fake pills and illicit drugs, DEA has also created a new
resource, “What Every Parent and Caregiver Needs to Know About Fake Pills.”
In September 2021, DEA launched the One Pill Can Kill enforcement effort and public awareness
campaign to combat the fake pill threat and educate the public about the dangers of fentanyl pills being
disguised and sold as prescription medications, despite these pills not containing any of the actual
medications advertised. The only safe medications are ones prescribed by a trusted medical
professional and dispensed by a licensed pharmacist. All other pills are unsafe and potentially deadly.
Additional resources for parents and the community can be found on DEA’s Fentanyl Awareness page.